The importance of screening for colorectal cancer has been established, but the decision about which test to use for each patient may seem less clear. In this article, Dr Wineman discusses assessment of colorectal cancer risk and the advantages and disadvantages of the fecal occult blood test, flexible sigmoidoscopy, double-contrast barium enema, and colonoscopy. Potential screening methods that could make regular colon examination more acceptable to patients also are presented.