Enteric fistulas are among the most dreaded surgical complications. Controlling fistula effluent and protecting the surrounding tissue is a difficult long-term endeavor that can consume significant clinical resources. This article describes novel, one-piece compressible isolation devices that can be used to manage the body surface around an enteric fistula, stoma, or drain tube to seal and protect the patient from effluent. The described devices and methods are the result of an innovative partnership between an abdominal reconstructive surgeon and a Certified Wound Ostomy Nurse (CWON) to deliver improved patient outcomes.