Background: The implementation of the Diabetes Prevention Program (DPP) with culturally diverse and low income participants has had varied success. The We Can Prevent Diabetes (WCPD) study was a pragmatic 3-arm cluster-randomized trial with Medicaid beneficiaries to evaluate the effectiveness of financial incentives on group-delivered DPP participation and weight loss. The purpose of this analysis is to identify participant and programmatic factors associated with 5% weight loss. Methods: Among Medicaid participants attending at least 4 of the 16 DPP core sessions, we examined factors associated with 5% weight loss at any time during the DPP core session period or a sustained 5% weight loss over the 16 sessions. The latter was determined using a latent class trajectory analysis. Univariate associations with p<0.2 were included in multivariable logistic models. Results: Among the 658 Medicaid beneficiaries in our analysis, 23% met each of the two outcome measures, 62% were 45-64 years old, 72% were women, 82% were not White, 26% were non-English speakers (Spanish, Somali, Hmong), 76% were obese, 18% received DPP program lead by a community member as a lifestyle coach, and 68% were in a financial incentive intervention arm. After adjustment, attending 9 or more sessions (OR 5.7, CI: 2.6-12.7), reporting physical activity 9 or more times (2.9, 1.4-5.9), and being a Non-English speaker (2.0, 1.2-3.7) were associated with achieving 5% weight loss at any time. Only the latter was associated with a sustained 5% weight loss (2.1, 1.3-3.6). After adjustment, allocation to a financial incentive arm was not associated with either of the 5% weight loss metrics. Conclusion: Session attendance and physical activity reporting may improve successful weight loss during the DPP program. Non- English speaking participants had the most success in achieving a sustained 5% weight loss. This may be due to tailoring the DPP curriculum to the specific culture, and using members of the community as lifestyle coaches.