Among many unintended and unexpected effects of sheltering in place during the COVID-19 pandemic is the substantial increase in exposures to indoor allergens and pollutants. Here, Dr. Edward Brooks at University of Texas at San Antonio and Dr. Charlene McEvoy at HealthPartners in Minnesota bring a shared expertise on air quality health and research to discuss the resulting health ramifications. It is an enlightening conversation about the patient populations who are most impacted, plus what can be done to help mitigate the consequences.