OBJECTIVES: The objective of this study was to explore patient perceptions and the practical implication of using a brief 9-item scale to screen for medication-related problems in community pharmacies. METHODS: Semistructured, audio-recorded, telephonic interviews were conducted with 40 patients who completed the scale and reviewed its results with their pharmacist. Audio recordings were transcribed verbatim and analyzed using qualitative methods to identify themes. RESULTS: Patients generally reported the scale was simple to complete and could be used easily in other community pharmacies. Participants shared they had increased understanding of their medications and confidence that their medication therapy was appropriate. Several patients reported having actual medication-related problems identified and resolved through the use of the scale. Patients also reported improved relationships with pharmacists and heightened belief in the value provided by pharmacists. CONCLUSIONS: This screening tool may have value in increasing patients' understanding of and confidence in their medications, enhancing pharmacist-patient relationships, and identifying problems requiring additional interventions.