Case: We present the case of a fifty-three-year-old man who presented with a necrotizing soft-tissue infection (NSTI) of the thumb, which tracked along the flexor pollicis longus tendon into the space of Parona. In this case report, we review the clinical and laboratory findings diagnostic of NSTI as well as the appropriate initial treatment for this challenging problem. Conclusion: NSTI is a rare, life threatening condition that must be identified and treated promptly for optimal results. In our patient, although we amputated the necrotic thumb, we were able to salvage the remaining hand and wrist despite more proximal involvement.