INTRODUCTION: Philosophy of practice is foundational to any patient care practice as it provides a set of professional values and beliefs that guide actions and decisions in practice. Philosophy of practice is a topic that has garnered attention in other health professions, but has received little emphasis within pharmacy. RESEARCH QUESTION OR HYPOTHESIS: (1) How do pharmacists providing comprehensive medication management (CMM) describe their philosophy of practice? (2) How do the identified components of participants’ philosophy of practice compare with the tenets of a CMM philosophy of practice? STUDY DESIGN: Qualitative content analysis. METHODS: This study was part of a large implementation and outcomes evaluation project enrolling 35 primary care clinics delivering CMM across five states. A survey with closed and open-ended items was developed and administered online to the lead pharmacist at each participating clinic. Each participant was asked to describe their philosophy of practice, rank how well their current practice activities align with the five CMM philosophy of practice tenets, provide examples of how they carry out each tenet, and how they could improve. Responses were coded and analyzed in NVivo. RESULTS: Thirty pharmacists completed the evaluation. A total of 12 unique codes emerged that participants used to describe their philosophy of practice. These codes were mapped to the five tenets. Only 3 (10%) participants included all five tenets in their philosophy of practice, 8 (26.7%) included four, 8 (26.7%) included three, 6 (20%) included two, and 5 (16.7%) included one tenet. CONCLUSION: There was significant variability in how participants described their philosophy of practice and how they incorporated existing tenets. To establish consistency across the practice of CMM, pharmacists should be exposed to and reflect on the philosophy of practice of CMM to ensure their services are in alignment with the core tenets.