Clinical care of the seriously poisoned patient is usually multidisciplinary, commonly involving various medical specialists, including emergency physicians, anesthesiologists, intensivists, and toxicologists. The role of a psychiatrist is sometimes overlooked, especially in texts that focus on the ABCs (airway, breathing, circulation) of toxicologic management. Reviews of the topic often make little or no mention of the psychiatric management of these patients. Yet patients who deliberately overdose have a high prevalence of suicidal ideation and pre-existing psychiatric disorders that may impact medical management, and it is also common for patients admitted to intensive care units (ICUs) to develop a psychiatric disturbance (e.g., delirium) during their admission, regardless of their premorbid psychiatric state.