John J. Marini, MD
Director of Physiological and Translational Research, Regions Hospital

Clinical Profile 

About

Title: Physician in pulmonary medicine, Regions Hospital

Education and training: MD, Johns Hopkins University School of Medicine; residency in internal medicine and fellowship in pulmonary medicine, University of Washington.

Overview/research interests: Cardiopulmonary physiology and management of acute respiratory failure, with an emphasis on patient-ventilator interactions occurring in that clinical setting. In most of his research, he has positioned himself at the interface between basic physiology and clinical medicine to develop insights into advancing clinical practice.

Current research activities and funding: Collaborating with colleagues who are well-versed in advanced imaging and biological sciences to explore questions of mutual interest.

Publications While At HealthPartners

selected publications

Journal Article
  • Impact of fluid balance on the development of lung injury
    American Journal of Respiratory and Critical Care Medicine. 2024
  • Mechanical power ratio threshold for ventilator-induced lung injury
    Intensive care medicine experimental. 2024
  • High- versus low-flow extracorporeal respiratory support in experimental hypoxemic acute lung injury
    American Journal of Respiratory and Critical Care Medicine. 2023
  • Lung injury is induced by abrupt increase in respiratory rate but prevented by recruitment maneuver in mild acute respiratory distress syndrome in rats
    Anesthesiology. 2023
  • Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome
    British Journal of Anaesthesia. 2023
  • Editorial Article
  • Are we ready to think differently about setting PEEP [editorial]?
    Critical Care (London, England).  26. 2022
  • In search of the Holy Grail: identifying the best PEEP in ventilated patients [editorial]
    Intensive Care Medicine.  48. 2022
  • Prone position and COVID-19: mechanisms and effects [editorial]
    Critical Care Medicine.  50. 2022
  • "Established" respiratory treatment in acute respiratory distress syndrome: scientific rigor or a square peg in a round hole [editorial]?
    American Journal of Respiratory and Critical Care Medicine.  203. 2021
  • COVID-19 and ARDS: the baby lung size matters [editorial]
    Intensive Care Medicine.  47. 2021
  • Chapter
  • Ventilatory management of obstructive airway disease
    Critical care medicine: principles of diagnosis and management in the adult. 2014
  • Position and the compromised respiratory system
    Annual update in intensive care and emergency medicine. 2012
  • Principles of gas exchange
    Textbook of critical care medicine. 2011
  • Consequences of pleural effusions for respiratory mechanics in ventilated patients
    Intensive Care Medicine 2010 Annual Update. 2010
  • Review
  • The ventilator of the future: key principles and unmet needs [review]
    Critical Care (London, England). 2024
  • COVID-19-related ARDS: key mechanistic features and treatments [review]
    Journal of clinical medicine. 2022
  • Chest wall loading in the ICU: pushes, weights, and positions [review]
    Annals of intensive care. 2022
  • The physiological underpinnings of life-saving respiratory support [review]
    Intensive Care Medicine. 2022
  • COVID-19 pneumonia: pathophysiology and management [review]
    European Respiratory Review: An Official Journal of the European Respiratory Society. 2021
  • Abstract
  • How does IAP affect esophageal pressure [abstract]?
    American Journal of Respiratory and Critical Care Medicine. 2013
  • Fowler's position reduces effusion-caused compressive lung stress and increases functional residual capacity [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2012
  • Intra-abdominal pressure transmission to the thorax is predominantly at end-inspiration [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2012
  • Tidal coefficient of variation as a predictor of weaning success [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2012
  • Does increased pre-trial respiratory pattern variability portend failure-to-wean [abstract]?
    American Journal of Respiratory and Critical Care Medicine. 2010
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