Skin sensitization induction risk assessment of common ingredients in commercially available cleansing conditioners [review] Review uri icon
Overview
abstract
  • BACKGROUND: An essential step in ensuring the toxicological safety of cosmetic or personal care products is the evaluation of the skin sensitizing potential of product ingredients. OBJECTIVE: We used a standardized protocol from cosmetic trade industry and consumer safety groups to evaluate the sensitization potential of ingredients in 3 commercially available cleansing conditioners. METHODS: A total of 33 ingredients were evaluated. Each ingredient underwent (1) dermatological evaluation, (2) in silico analysis for irritation and sensitization potential, and (3) a literature evaluation to determine risk of sensitization. Consumer exposure level was compared with the weight-of-evidence no-expected sensitization induction level for the constituent. If a no-expected sensitization induction level for a specific ingredient was not available, the dermal sensitization threshold approach was used. A margin of safety was calculated for each constituent. RESULTS: The margins of safety for all evaluated ingredients in the cleansing conditioners were greater than 1. CONCLUSIONS: This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario.

  • Link to Article
    publication date
  • 2019
  • published in
  • Dermatitis  Journal
  • Research
    keywords
  • Adverse Effects
  • Rhinitis, Allergic
  • Risk Assessment
  • Simulation
  • Skin Diseases
  • Additional Document Info
    volume
  • 30
  • issue
  • 2