Neuroscience Research Centers

About

We conduct clinical trials and observational studies in the areas of brain and spine disorders. This includes memory loss, dementia, stroke, Parkinson’s disease and spinal cord injury. Our neuroscience research teams work through  Struthers Parkinson's Center 

 and the Center for Memory & Aging .  An additional area of focus is on intranasal drug delivery.

Overview

contributor

  • Haake, Bret C., MD   Clinical Research Investigator  

    • Affiliation

    people

    Faculty Position
  • Barclay, Terry R., PhD, LP, Research investigator, Center for Memory & Aging, Regions Hospital 2009 -
  • Fine, Jared M., PhD, Research Associate 2006 -
  • Frey II, William H., PhD, Sr. Director 1977 -
  • Guliani, Gaurav K., MD, Research Investigator
  • Haake, Bret C., MD, Research Investigator

    • Publications While At HealthPartners

    selected publications

    Journal Article
  • Acupuncture treatment for chronic post-traumatic headache in individuals with mild traumatic brain injury: a pilot study. 
    Journal of Neurotrauma. 2025
  • Distinguishing prodromal dementia with Lewy bodies from prodromal Alzheimer disease: a longitudinal study. 
    Neurology. Clinical practice. 2025
    Article has an altmetric score of 11  
  • Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer's disease. 
    Frontiers in Neuroscience. 2025
    Article has an altmetric score of 10  
  • Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology. 
    Journal of Alzheimer's disease reports. 2025
    Article has an altmetric score of 11  
  • Clinical and cognitive features associated with psychosis in Parkinson's disease: a longitudinal study. 
    Frontiers in Aging Neuroscience. 2024
    • Editorial Article
  • Recommendations for virtual administration of the PSP Rating Scale [editorial]. 
    Movement Disorders.  37. 2022
    Article has an altmetric score of 2  
  • Intronic pentanucleotide expansion in the replication factor 1 gene (RFC1) is a major cause of adult-onset ataxia [editorial]. 
    Neurology. Genetics.  6. 2020
    Article has an altmetric score of 2
  • Attention training improves attention and gait in Parkinson disease: a pilot study [editorial]. 
    Parkinsonism & Related Disorders.  60. 2019
  • Defining pediatric Huntington disease: time to abandon the term Juvenile Huntington Disease [editorial]?. 
    Movement Disorders.  34. 2019
  • Parkinson's disease physiotherapy: specialisation adds value [editorial]. 
    Lancet Neurology.  17. 2018
    Article has an altmetric score of 10  
    • Conference Paper
  • Intranasal delivery bypasses the blood-brain barrier to deliver and target insulin and other therapeutics to the central nervous system [invited speaker]
    2013
  • Intranasal delivery bypasses the blood-brain barrier to deliver and target stem cells and other therapeutics to the central nervous system [invited speaker]
    2013
  • Intranasal delivery bypasses the blood-brain barrier to deliver and target therapeutics to the central nervous system [invited speaker]
    2013
  • Intranasal delivery bypasses the blood-brain barrier to deliver and target therapeutics to the central nervous system [invited speaker]
    2013
  • Intranasal delivery bypasses the blood-brain barrier to deliver and target therapeutics to the central nervous system [invited speaker]
    2013
    • Conference Poster
  • Outcomes of an embedded resource and education program for patients and families with memory loss [poster]
    2017
  • Performance on cognitive screening is associated with increased retrospective healthcare utilization [poster]
    2015
  • Pharmacokinetics of a diazepam prodrug/enzyme combination following nasal administration in rats for treatment of seizure emergencies [poster]
    2015
  • Routine cognitive screening in a neurology practice: impact on physician behavior [poster]
    2015
  • The Minnesota Memory Project: baseline data from a longitudinal observational study of aging [poster]
    2015
    • Review
  • Brain glucose hypometabolism and brain iron accumulation as therapeutic targets for Alzheimer's disease and other CNS disorders [review]. 
    Pharmaceuticals (Basel, Switzerland). 2025
    Article has an altmetric score of 1  
  • How do researchers identify and recruit dementia caregivers? A scoping review [review]. 
    The Gerontologist. 2025
  • Neuropsychological test performance in mild cognitive impairment with Lewy bodies: a systematic review and meta-analysis [systematic review, meta-analysis, review]. 
    Alzheimer's & dementia. 2025
    Article has an altmetric score of 74  
  • Differentiating prodromal dementia with Lewy bodies from prodromal Alzheimer's disease: a pragmatic review for clinicians [review]. 
    Neurology and therapy. 2024
    Article has an altmetric score of 18  
  • Factors associated with increased health care utilization for patients with dementia with Lewy bodies: a narrative review [review]. 
    Journal of patient-centered research and reviews. 2024
    Article has an altmetric score of 7  
    • Abstract
  • A retrospective study evaluating the use of anti-Parkinsonian medications in patients with advanced Parkinson's disease treated with Levodopa-Carbidopa Intestinal Gel and deep brain stimulation [abstract]. 
    Journal of the Neurological Sciences. 2021
  • IMPACT Learning Health Network: transforming care through embedded pragmatic clinical trials in health care settings that serve people with dementia [abstract]. 
    Journal of patient-centered research and reviews. 2021
    Article has an altmetric score of 199  
  • The NIA IMPACT Collaboratory: transforming dementia care rhrough embedded pragmatic clinical trials [abstract]
    2020
  • Implementation of a mindfulness based dementia-care program within a healthcare system [abstract]. 
    Innovation in aging. 2019
  • Chord Study: the power of music through participation in the giving voice chorus [abstract]. 
    Alzheimer's & dementia. 2018
    • Audio Document
  • How bystander CPR improves the odds of survival [podcast]
    2024
  • Living with a sudden and life-changing physical disability [podcast]
    2024
  • Minneapolis schools heal and transform through grief and trauma [podcast]
    2024
  • Access to youth sports [podcast]
    2023
  • Belonging, burnout and the importance of well-being [podcast]
    2023
    • Audio-Visual Document
  • The waiting room (on Alzheimer's disease). Broadcast on FM107 Radio.
    2016
    • Book
  • Caregiver guide for mid to late stage Huntington's disease: for long-term care facilities and in-home care agencies
    2015
    • Document
  • Intranasal administration of deferoxamine for the prevention or treatment of stroke is hemodynamically safe compared to intravenous administration
    2007
  • Intranasal delivery bypasses the blood-brain barrier to target drugs to the CNS and reduce systemic exposure
    2007
  • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system (CNS)
    2007
  • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system (CNS) to treat Alzheimer's, stroke and other disorders
    2007
  • Intranasal delivery bypasses the blood-brain barrier to target therapeutics to the brain to improve memory in human adults and those with Alzheimer's disease and treat CNS (central nervous system) disorders in animal models
    2007
    • Patent
  • Methods for protecting and treating traumatic brain injury and concussion with intranasal insulin
    2021
  • Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
    2021
  • Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
    2021
  • Methods for treating patients with impaired awareness of hypoglycemia
    2021
  • Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system
    2017

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