Understanding the social determinants of health (SDoH), social risk factors, and health-related social needs (HRSN) is critical to creating equitable health and care for all patients and communities. Health care systems need to understand their role in enacting relevant strategies, processes, and policies. One way that health care systems can explore what processes and policies work for their patients and their community is using the Plan-Do-Study-Act (PDSA) model. This discussion paper provides frameworks and approaches to using PDSA cycles to implement SDoH, social risk factors, and HRSN efforts, as a follow-up to the 2017 NAM Perspectives discussion paper Social Determinants of Health 101 for Health Care: Five Plus Five [1].