Supratherapeutic antibiotic levels and acute kidney injury from absorption of topical antibiotics: a case report Journal Article uri icon
Overview
abstract
  • CASE: A 96-year-old woman with no baseline renal dysfunction presented with a distal femoral shaft fracture after a ground-level fall. Treatment was with a retrograde intramedullary nail and included placement of topical antibiotics. Postoperatively, she developed acute kidney injury and was found to have supratherapeutic antibiotic levels. CONCLUSION: This case report demonstrates the risk of clinically relevant systemic absorption along with associated downstream end organ damage with the use of topical antibiotics in certain circumstances. We present this case as an illustration of a rare hazard associated with topical antibiotic use.

  • Link to Article
    publication date
  • 2022
  • published in
    Research
    keywords
  • Adverse Effects
  • Drugs and Drug Therapy
  • Fractures
  • Injuries
  • Kidney
  • Orthopedics
  • Surgery
  • Additional Document Info
    volume
  • 12
  • issue
  • 2