The HealthPartners Institute is a research and education division embedded within HealthPartners — a nonprofit, member-governed integrated health system. The Institute aims to generate and accelerate innovation for the HealthPartners health system, its patients and members, and the communities it serves. It has taken a formal, organized approach to building the necessary capabilities, infrastructures, relationships, and tools to do so. This article outlines an innovative approach by which the HealthPartners Institute created an environment conducive to accelerated system performance.