Malini B. DeSilva, MD, MPH
Senior Research Investigator, MD
"Health disparities issues have been the foundation of both my clinical and research interests, in particular I have worked to address health challenges among vulnerable populations including non-English speaking persons. I attempt to promote health equity through my research by providing evidence needed support policy change."
About
Dr. Malini B. DeSilva is a Senior Research Investigator and the Co-Director of the Pregnancy and Child Health Research Center at HealthPartners Institute. She is also an affiliated faculty at the University of Minnesota in the Department of Medicine’s Global Health Pathway and a practicing physician for both the HealthPartners Travel & Tropical Medicine Department and the St. Paul-Ramsey County Tuberculosis Clinic. She received her MD from Mayo Medical School and an MPH from the University of Minnesota School of Public Health. Dr. DeSilva completed her Med-Peds residency at the University of Minnesota and is double boarded in both internal medicine and pediatrics. Following residency, she completed the Centers for Disease Control and Prevention’s Epidemic Intelligence Service.

Dr. DeSilva’s current research focuses primarily on refugee and immigrant health and vaccine preventable diseases. Health disparities issues have been at the center of both her clinical and research interests, particularly focused on non-English speaking populations and addressing vaccine safety issues in pregnant persons. She is the lead HealthPartners investigator for two CDC funded research networks, the Center of Excellence in Newcomer Health and VISION (Virtual Network: Investigating the Risk of COVID-19-Associated Outcomes and COVID-19 Vaccine Effectiveness Using Integrated Medical and Public Health Records).

Other offices/titles: Staff physician, HealthPartners Department of Infectious Diseases and Travel and Tropical Medicine Center; staff physician, St. Paul-Ramsey County Tuberculosis Clinic

Joined the Institute: 2019

Education and training: MD, Mayo Medical School, Rochester, MN; MPH, University of Minnesota School of Public Health, Minneapolis; Certificate of Tropical Medicine, University of Minnesota, Minneapolis.

Overview/research interests: Refugee health, vaccine-preventable diseases, health disparities, and integration of public health and medicine.

Current research activities and funding:

  • Vaccine Safety DataLink
  • Effectiveness of Maternal Tdap Administration on Infant Pertussis Disease
  • Team-Based and Technology-Drive Adherence Intervention to Improve Chronic Disease Outcomes
  • Hotspotting Cardiometabolic Disparities for Simulated Advances in Population Care
  • The CENTER: Center of Excellence, a Network for Training and Epidemiology in Refugee Health
Affiliation
positions
  • Sr. Research Investigator, Vaccines
  • Sr. Research Investigator, Pregnancy and child health 2019 -
  • Publications While At HealthPartners
    selected publications
    Journal Article
  • 18 Years - VISION and IVY Networks, September 2023-January 2024
    MMWR: Morbidity and Mortality Weekly Report. 2024
  • COVID-19 vaccination in the first trimester and major structural birth defects among live births
    JAMA pediatrics. 2024
  • COVID-19 vaccine uptake among non-US-born populations in the United States, 2020-2022
    Vaccine. 2024
  • Clinical epidemiology and risk factors for critical outcomes among vaccinated and unvaccinated adults hospitalized with COVID-19-VISION Network, 10 states, June 2021-March 2023
    Clinical Infectious Diseases. 2024
  • Coronavirus disease 2019 (COVID-19) vaccination and stillbirth in the Vaccine Safety Datalink
    Obstetrics and Gynecology. 2024
  • Impact of the COVID-19 pandemic on health care utilization in the Vaccine Safety Datalink: retrospective cohort study
    JMIR public health and surveillance. 2024
  • Influenza vaccine effectiveness against influenza A-associated emergency department, urgent care, and hospitalization encounters among US adults, 2022-2023
    Journal of Infectious Diseases. 2024
  • Interim estimates of 2023-24 seasonal influenza vaccine effectiveness - United States
    MMWR: Morbidity and Mortality Weekly Report. 2024
  • Lack of evidence for vaccine-associated enhanced disease from COVID-19 vaccines among adults in the Vaccine Safety Datalink
    Pharmacoepidemiology and Drug Safety. 2024
  • Obstetric complications and birth outcomes after antenatal coronavirus disease 2019 (COVID-19) vaccination
    Obstetrics and Gynecology. 2024
  • Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis
    Lancet (London, England). 2024
  • Risk of COVID-19 hospitalization and protection associated with mRNA vaccination among US adults with psychiatric disorders
    Influenza and other respiratory viruses. 2024
  • Time to COVID-19 vaccination by language and country of origin
    JAMA network open. 2024
  • Vaccine effectiveness against SARS-CoV-2 related hospitalizations in people who had experienced homelessness or incarceration - findings from the Minnesota EHR Consortium
    Journal of Community Health. 2024
  • Vaccine effectiveness against pediatric influenza-A-associated urgent care, emergency department, and hospital encounters during the 2022-2023 season: VISION Network
    Clinical Infectious Diseases. 2024
  • COVID-19 booster vaccination in early pregnancy and surveillance for spontaneous abortion
    JAMA network open. 2023
  • COVID-19 vaccine safety surveillance in early pregnancy in the United States: design factors affecting the association between vaccine and spontaneous abortion
    American Journal of Epidemiology. 2023
  • Effectiveness of BNT162b2 COVID-19 vaccination in children and adolescents
    Pediatrics. 2023
  • Effectiveness of COVID-19 vaccines at preventing emergency department or urgent care encounters and hospitalizations among immunocompromised adults: an observational study of real-world data across 10 US states from August-December 2021
    Vaccine. 2023
  • Estimates of bivalent mRNA vaccine durability in preventing COVID-19-associated hospitalization and critical illness among adults with and without immunocompromising conditions - VISION Network, September 2022-April 2023
    American Journal of Transplantation. 2023
  • Estimation of COVID-19 mRNA vaccine effectiveness and COVID-19 illness and severity by vaccination status during Omicron BA.4 and BA.5 sublineage periods
    JAMA network open. 2023
  • Implementation of bedaquiline, pretomanid, and linezolid in the United States: experience using a novel all-oral treatment regimen for treatment of rifampin-resistant or rifampin-intolerant tuberculosis disease
    Clinical Infectious Diseases. 2023
  • Increasing COVID-19 vaccination coverage for newcomer communities: the importance of disaggregation by language
    American Journal of Tropical Medicine and Hygiene. 2023
  • Medically attended acute adverse events in pregnant people after coronavirus disease 2019 (COVID-19) booster vaccination
    Obstetrics and Gynecology. 2023
  • Number needed to vaccinate with a COVID-19 booster to prevent a COVID-19-associated hospitalization during SARS-CoV-2 Omicron BA.1 variant predominance, December 2021-February 2022, VISION Network: a retrospective cohort study
    Lancet Reg Health Am. 2023
  • Patient and epidemiological factors associated with influenza testing in hospitalized adults with acute respiratory illnesses, 2016-2017 to 2019-2020
    Open forum infectious diseases. 2023
  • Protection from COVID-19 mRNA vaccination and prior SARS-CoV-2 infection against COVID-19-associated encounters in adults during Delta and Omicron predominance
    Journal of Infectious Diseases. 2023
  • Protection of two and three mRNA vaccine doses against severe outcomes among adults hospitalized with COVID-19--VISION Network, August 2021 to March 2022
    Journal of Infectious Diseases. 2023
  • Relationships between social vulnerability and coronavirus disease 2019 vaccination coverage and vaccine effectiveness
    Clinical Infectious Diseases. 2023
  • Safety of measles, mumps, and rubella vaccine in adolescents and adults in the Vaccine Safety Datalink
    Vaccine. 2023
  • Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes
    Vaccine. 2023
  • Vaccine effectiveness against influenza-associated urgent care, emergency department, and hospital encounters during the 2021-2022 season, VISION Network
    Journal of Infectious Diseases. 2023
  • Association of the COVID-19 pandemic with routine childhood vaccination rates and proportion up to date with vaccinations across 8 US health systems in the Vaccine Safety Datalink
    JAMA pediatrics. 2022
  • Cancer screening in refugees and immigrants: a global perspective
    American Journal of Tropical Medicine and Hygiene. 2022
  • Changes in incidence rates of outcomes of interest in vaccine safety studies during the COVID-19 pandemic
    Vaccine. 2022
  • Early estimates of bivalent mRNA vaccine effectiveness in preventing COVID-19-associated emergency department or urgent care encounters and hospitalizations among immunocompetent adults - VISION Network, nine states, September-November 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of 2, 3, and 4 COVID-19 mRNA vaccine doses among immunocompetent adults during periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 sublineages predominated - VISION Network, 10 states, December 2021-June 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of BNT162b2 and mRNA-1273 second doses and boosters for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and SARS-CoV-2-related hospitalizations: a statewide report from the Minnesota Electronic Health Record Consortium
    Clinical Infectious Diseases. 2022
  • Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA vaccination in preventing COVID-19-associated emergency department and urgent care encounters and hospitalizations among nonimmunocompromised children and adolescents aged 5-17 years - VISION Network, 10 states, April 2021-January 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of COVID-19 mRNA vaccines against COVID-19-associated hospitalizations among immunocompromised adults during SARS-CoV-2 Omicron predominance - VISION Network, 10 states, December 2021-August 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of a third dose of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during oeriods of Delta and Omicron variant predominance - VISION Network, 10 states, August 2021-January 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of homologous and heterologous COVID-19 booster doses following 1 Ad.26.COV2.S (Janssen (Johnson & Johnson)) vaccine dose against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults - VISION Network, 10 states, December 2021-March 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults-nine states, January-September 2021
    American Journal of Transplantation. 2022
  • Evaluation of acute adverse events after Covid-19 vaccination during pregnancy
    New England Journal of Medicine. 2022
  • How to make up for rotavirus vaccination missed during the COVID-19 pandemic?-Reply
    JAMA pediatrics. 2022
  • Improving care for patients with chronic hepatitis B via establishment of a disease registry
    American Journal of Tropical Medicine and Hygiene. 2022
  • Kawasaki disease following the 13-valent pneumococcal conjugate vaccine and rotavirus vaccines
    Pediatrics. 2022
  • Minnesota Electronic Health Record Consortium COVID-19 Project: informing pandemic response through statewide collaboration using observational data
    Public Health Reports. 2022
  • Monitoring vaccine safety using the Vaccine Safety Datalink: assessing capacity to integrate data from Immunization Information systems
    Vaccine. 2022
  • Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birth - eight integrated health care organizations, United States, December 15, 2020-July 22, 2021
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Travelers and travel vaccines at six health care systems in the Vaccine Safety Datalink
    Vaccine. 2022
  • Trends in COVID-19 vaccine administration and effectiveness through October 2021
    JAMA network open. 2022
  • Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during periods of Delta and Omicron variant predominance - VISION Network, 10 states, August 2021-January 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study
    BMJ (Clinical research ed.). 2022
  • Antimicrobial use in a cohort of US nursing homes, 2017
    JAMA. 2021
  • Association of inadvertent 9-valent human papillomavirus vaccine in pregnancy with spontaneous abortion and adverse birth outcomes
    JAMA network open. 2021
  • COVID-19 vaccination coverage among pregnant women during pregnancy - eight integrated health care organizations, United States, December 14, 2020-May 8, 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Developing algorithms for identifying major structural birth defects using automated electronic health data
    Pharmacoepidemiology and Drug Safety. 2021
  • Drug-dispensing limits within Medicaid during the COVID-19 pandemic
    Journal of managed care & specialty pharmacy. 2021
  • Effectiveness of 2-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults - nine states, January-September 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings
    New England Journal of Medicine. 2021
  • Hepatitis B evaluation and linkage to care for newly arrived refugees: a multisite quality improvement initiative
    Journal of immigrant and minority health. 2021
  • Interim estimates of COVID-19 vaccine effectiveness against COVID-19-associated emergency department or urgent care clinic encounters and hospitalizations among adults during SARS-CoV-2 B.1.617.2 (Delta) variant predominance - nine states, June-August 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Laboratory-confirmed COVID-19 among adults hospitalized with COVID-19-like illness with infection-induced or mRNA vaccine-induced SARS-CoV-2 immunity - nine states, January-September 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Spontaneous abortion following COVID-19 vaccination during pregnancy
    JAMA. 2021
  • A best practice alert for identifying hepatitis B-infected patients
    American Journal of Tropical Medicine and Hygiene. 2020
  • Assessment of health care exposures and outcomes in adult patients with sepsis and septic shock
    JAMA network open. 2020
  • Effects of the COVID-19 pandemic on routine pediatric vaccine ordering and administration - United States, 2020
    MMWR: Morbidity and Mortality Weekly Report. 2020
  • Epidemiology of antibiotic use for urinary tract infection in nursing home residents
    Journal of the American Medical Directors Association. 2020
  • Evaluation of a program to improve linkage to and retention in care among refugees with hepatitis B virus infection - three U.S. cities, 2006-2018
    MMWR: Morbidity and Mortality Weekly Report. 2020
  • Congenital microcephaly: case definition & guidelines for data collection, analysis, and presentation of safety data after maternal immunisation
    Vaccine. 2017
  • Maternal Tdap vaccination and risk of infant morbidity
    Vaccine. 2017
  • Congenital anomalies: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data
    Vaccine. 2016
  • Tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring
    JAMA. 2016
  • Notes from the field: fatal yellow fever vaccine-associated viscerotropic disease--Oregon, September 2014
    MMWR: Morbidity and Mortality Weekly Report. 2015
  • Editorial Article
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