Pawloski, Pamala A., PharmD, BCOP, FCCP

Pamala A. Pawloski, PharmD, BCOP, FCCP

Former Senior Research Investigator

About

Joined the Institute: 2008

Education and training: PharmD, North Dakota State University; pharmacy practice residency and oncology pharmacy practice residency, University of Kentucky; clinical pharmacology fellowship, University of Texas M.D. Anderson Cancer Center.

Overview/research interests: Optimizing patient outcomes by improving medication management through the application of pharmacogenomics, medication therapy management and medication surveillance.

Current research activities and funding:

Cancer Treatment and Supportive Care Outcomes

CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems (NCI)
Pilot Testing a Biorepository Framework to Enable Genomic Research at HP (HPI)
Treatment, Experiences and Barriers among Elderly Colorectal Cancer Patients (PCORI)
Implementing Universal Lynch Syndrome Screening across Multiple Healthcare Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts (NCI)

Medication Safety and Adverse Event Surveillance

Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) Maintenance (FDA)
Evaluation of the Risk of Neural Tube Defects Among Live Births Exposed to Maternal Prescription Opioids During Early Pregnancy (FDA)
FDA Sentinel Initiative (FDA)
Innovation in Medical Evidence and Development Surveillance (IMEDS) Signal Refinement and Signal Characterization Bundles (public-private
Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) Comparative Effectiveness of Biosimilars (public-private)

Publications While At HealthPartners

selected publications

Journal Article

A power-based sliding window approach to evaluate the clinical impact of rare genetic variants in the nucleotide sequence or the spatial position of the folded protein.

HGG Adv. 2024

Identifying factors and causal chains associated with optimal implementation of Lynch syndrome tumor screening: an application of coincidence analysis.

Genetics in Medicine. 2024

Protocol of a patient randomized clinical trial to improve medication adherence in primary care.

Contemporary Clinical Trials. 2024

Risk of arterial and venous thrombotic events among patients with COVID-19: a multi-national collaboration of regulatory agencies from Canada, Europe, and United States.

Clinical Epidemiology. 2024

SARS-CoV-2 antiviral prescribing gaps among non-hospitalized high-risk adults.

Clinical Infectious Diseases. 2024

Utilization and patient characteristics for the trastuzumab reference and biosimilars, and other human epidermal growth factor receptor 2 inhibitors in the United States.

Journal of managed care & specialty pharmacy. 2024

"Go ahead and screen" - advice to healthcare systems for routine lynch syndrome screening from interviews with newly diagnosed colorectal cancer patients.

Hereditary Cancer in Clinical Practice. 2023

A picture is worth a thousand words: advancing the use of visualization tools in implementation science through process mapping and matrix heat mapping.

Implement Sci Commun. 2023

Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program.

PloS One. 2023

Identification of cancer chemotherapy regimens and patient cohorts in administrative claims: challenges, opportunities, and a proposed algorithm.

Journal of Medical Economics. 2023

Risk of admission to hospital with arterial or venous thromboembolism among patients diagnosed in the ambulatory setting with covid-19 compared with influenza: retrospective cohort study.

BMJ Med. 2023

Association of COVID-19 vs influenza with risk of arterial and venous thrombotic events among hospitalized patients.

JAMA. 2022

Characteristics of state legislation addressing prescription drug price increases in the United States, 2020.

Journal of General Internal Medicine. 2022

Comparing pharmacist-led telehealth care and clinic-based care for uncontrolled high blood pressure: the Hyperlink 3 pragmatic cluster-randomized trial.

Hypertension (Dallas, Tex.. 2022

Comparison of explanatory and pragmatic design choices in a cluster-randomized hypertension trial: effects on enrollment, participant characteristics, and adherence.

Trials. 2022

Demographic differences in willingness to share electronic health records in the All of Us Research Program.

Journal of the American Medical Informatics Association. 2022

Developing an algorithm across integrated healthcare systems to identify a history of cancer using electronic medical records.

Journal of the American Medical Informatics Association. 2022

Patient characteristics, pain treatment patterns, and incidence of total joint replacement in a US population with osteoarthritis.

BMC Musculoskeletal Disorders. 2022

Should health systems share genetic findings with at-risk relatives when the proband is deceased? Interviews with individuals diagnosed with Lynch syndrome.

Journal of patient-centered research and reviews. 2022

The association of bowel function, participation in life activities, and quality of life in rectal cancer survivors.

Quality of Life Research. 2022

Using the IMEDS distributed database for epidemiological studies in type 2 diabetes mellitus.

BMJ open diabetes research & care. 2022

Validation of diagnosis codes to identify hospitalized COVID-19 patients in health care claims data.

Pharmacoepidemiology and Drug Safety. 2022

A randomized trial of medical cannabis in patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient satisfaction.

Supportive Care in Cancer. 2021

Assessment of oral chemotherapy nonadherence in chronic myeloid leukemia patients using brief measures in community cancer clinics: a pilot study.

International Journal of Environmental Research and Public Health. 2021

BBCIC Research Network analysis of first-cycle prophylactic G-CSF use in patients treated with high-neutropenia risk chemotherapy.

Journal of the National Comprehensive Cancer Network. 2021

Patient characteristics and utilization patterns of short-acting recombinant granulocyte colony-stimulating factor (G-CSF) biosimilars compared to their reference product.

Drugs - real world outcomes. 2021

Pharmacogenomics education, research and clinical implementation in the state of Minnesota.

Pharmacogenomics. 2021

Population characteristics, use, and spending on sole-source, off-patent drugs among commercial insurance members in the United States—an analysis of outpatient claims data at a single health plan.

Journal of the American College of Clinical Pharmacy. 2021

Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014.

Pharmacoepidemiology and Drug Safety. 2021

A population-based survey to assess the association between cannabis and quality of life among colorectal cancer survivors.

BMC cancer. 2020

Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence.

Breast Cancer Research and Treatment. 2020

Cardiovascular events and costs with home blood pressure telemonitoring and pharmacist management for uncontrolled hypertension.

Hypertension (Dallas, Tex.. 2020

Characteristics and price increases among sole-source, off-patent drugs in the United States, 2008 to 2018.

JAMA network open. 2020

Design of a pragmatic cluster-randomized trial comparing telehealth care and best practice clinic-based care for uncontrolled high blood pressure.

Contemporary Clinical Trials. 2020

Developing a standardized and reusable method to link distributed health plan databases to the National Death Index: methods development study protocol.

JMIR research protocols. 2020

Validity of diagnosis and procedure codes for identifying neural tube defects in infants.

Pharmacoepidemiology and Drug Safety. 2020

Variation in colorectal cancer stage and mortality across large community-based populations: PORTAL Colorectal Cancer Cohort.

The Permanente journal. 2020

Clinical molecular marker testing data capture to promote precision medicine research within the Cancer Research Network.

JCO clinical cancer informatics. 2019

Descriptive analysis of long- and intermediate-acting insulin and key safety outcomes in adults with type 2 diabetes mellitus.

Journal of managed care & specialty pharmacy. 2019

Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to evaluate patterns of care.

Journal of managed care & specialty pharmacy. 2019

Health care improvement and survivorship priorities of colorectal cancer survivors: findings from the PORTAL colorectal cancer cohort survey.

Supportive Care in Cancer. 2019

Psycho-Oncology. 2019

Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018.

PloS One. 2019

Long-term patterns of oral anticancer agent adoption, duration, and switching in patients with CML.

Journal of the National Comprehensive Cancer Network. 2019

PCSK9 inhibitor use in the real world: data From the National Patient-Centered Research Network.

Journal of the American Heart Association. 2019

Predictors of long-term survival among high-grade serous ovarian cancer patients.

Cancer Epidemiology, Biomarkers and Prevention. 2019

Pregnancy-associated cancer: a U.S. population-based study.

Journal of women's health (2002). 2019

The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine.

EGEMS (Washington, DC). 2019

Treatment patterns and survival differ between early-onset and late-onset colorectal cancer patients: the patient outcomes to advance learning network.

Cancer Causes and Control. 2019

Unique case report of a meningeal sarcoma arising during ongoing treatment for progressing intraparenchymal glioma

2019

Economic evaluation of the home blood pressure telemonitoring and pharmacist case management to control hypertension (Hyperlink) trial.

Journal of the American College of Clinical Pharmacy. 2018

Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts.

BMC Health Services Research. 2018

Key components of success in a randomized trial of blood pressure telemonitoring with medication therapy management pharmacists.

Journal of the American Pharmacists Association. 2018

Long-term outcomes of the effects of home blood pressure telemonitoring and pharmacist management on blood pressure among adults with uncontrolled hypertension: follow-up of a cluster randomized clinical trial.

JAMA network open. 2018

Navigating the complex landscape of genetic testing: genetics professionals are a key resource.

MetroDoctors. 2018

Opioid use during pregnancy, observations of opioid use, and secular trend from 2006 to 2014 at HealthPartners Medical Group.

Clinical Journal of Pain. 2018

Accuracy of electronic health record-derived data for the identification of incident ADHD

2017

Establishment of personalized pain goals in oncology patients to improve care and decrease costs.

Journal of Oncology Practice. 2017

Optimizing patient-reported outcome and risk factor reporting from cancer survivors: a randomized trial of four different survey methods among colorectal cancer survivors.

Journal of Cancer Survivorship. 2017

Predicting neutropenia risk in patients with cancer using electronic data.

Journal of the American Medical Informatics Association. 2017

The financial toll of cancer therapy: developing ways to help the patient.

Minn Physician. 2017

Training in the conduct of population-based multi-site and multi-disciplinary studies: the Cancer Research Network's Scholars Program.

Journal of Cancer Education. 2017

A substudy evaluating treatment intensification on medication adherence among hypertensive patients receiving home blood pressure telemonitoring and pharmacist management.

Journal of Clinical Pharmacy and Therapeutics. 2016

Patient characteristics associated with greater blood pressure control in a randomized trial of home blood pressure telemonitoring and pharmacist management.

Journal of the American Society of Hypertension. 2016

Pegfilgrastim use and bone pain: a cohort study of community-based cancer patients.

Journal of Oncology Pharmacy Practice. 2016

Proton pump inhibitor use by aspirin-treated coronary artery disease patients is not associated with increased risk of cardiovascular events.

European heart journal. Cardiovascular pharmacotherapy. 2016

The Cancer Research Network: a platform for epidemiologic and health services research on cancer prevention, care, and outcomes in large, stable populations.

Cancer Causes and Control. 2016

Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies.

Pharmacoepidemiology and Drug Safety. 2016

A successful multifaceted trial to improve hypertension control in primary care: why did it work?.

Journal of General Internal Medicine. 2015

Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.

Pharmacoepidemiology and Drug Safety. 2015

Chronic opioid use emerging after bariatric surgery.

Pharmacoepidemiology and Drug Safety. 2014

Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer.

Breast Cancer Research and Treatment. 2014

Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample.

PloS One. 2014

Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study.

Breast Cancer Research and Treatment. 2014

Pharmacotherapy for incident attention-deficit/hyperactivity disorder: practice patterns and quality metrics.

Current Medical Research and Opinion. 2014

Phase II study of biweekly carboplatin, gemcitabine, and bevacizumab as first-line treatment in patients with stage IIIB/IV NSCLC.

American Journal of Clinical Oncology. 2014

The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007.

Maternal and child health journal. 2014

Trends in elective labor induction for six United States health plans, 2001-2007.

Journal of women's health (2002). 2014

Barriers to and facilitators of medication adherence.

American Journal of Pharmacy Benefits. 2013

Chronic use of opioid medications before and after bariatric surgery.

JAMA. 2013

Drug adverse event detection in health plan data using the gamma poisson shrinker and comparison to the tree-based scan statistic.

Pharmaceutics. 2013

Drug safety data mining with a tree-based scan statistic.

Pharmacoepidemiology and Drug Safety. 2013

Fracture risk in older, long-term survivors of early-stage breast cancer.

Journal of the American Geriatrics Society. 2013

Incident malignancies among older long-term breast cancer survivors and an age-matched and site-matched nonbreast cancer comparison group over 10 years of follow-up.

Cancer. 2013

KRAS testing and epidermal growth factor receptor inhibitor treatment for colorectal cancer in community settings.

Cancer Epidemiology, Biomarkers and Prevention. 2013

Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy.

Maternal and child health journal. 2013

Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes.

Pharmacoepidemiology and Drug Safety. 2013

Oncologists' attitudes toward KRAS testing: a multisite study.

Cancer medicine. 2013

Patient characteristics associated with medication adherence.

Clinical Medicine & Research. 2013

Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries

2013

Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007.

Obstetrics and Gynecology. 2013

Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer.

Genetics in Medicine. 2013

Validation of an algorithm to estimate gestational age in electronic health plan databases.

Pharmacoepidemiology and Drug Safety. 2013

Validation of anaphylaxis in the Food and Drug Administration's Mini-Sentinel.

Pharmacoepidemiology and Drug Safety. 2013

Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database.

Pharmacoepidemiology and Drug Safety. 2013

Validity of health plan and birth certificate data for pregnancy research.

Pharmacoepidemiology and Drug Safety. 2013

Development of clinical pharmacy productivity metrics.

American Journal of Health-System Pharmacy. 2012

Medication Exposure in Pregnancy Risk Evaluation Program.

Maternal and child health journal. 2012

The genome comes to the clinic: using pharmacogenetic data for treatment-related decisions.

Minn Physician. 2012

Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study.

Paediatric and Perinatal Epidemiology. 2012

ADHD medications and risk of serious cardiovascular events in young and middle-aged adults.

JAMA. 2011

Age, comorbidity, and breast cancer severity: impact on receipt of definitive local therapy and rate of recurrence among older women with early-stage breast cancer.

Journal of the American College of Surgeons. 2011

Editorial Article

Cancer screening results and follow-up using routinely collected electronic health data: estimates for breast, colon, and cervical cancer screenings [editorial].

Journal of General Internal Medicine. 34. 2019

How clinical pharmacists can improve outpatient diabetes care [editorial].

Diabetes Management (London, England). 4. 2014

Personalized and prioritized diabetes treatment recommendations to reduce cardiovascular risk [editorial]

2014

Chapter

Health maintenance organizations/health plans.

Pharmacoepidemiology. 2012

Conference Paper

Validation of genomic markers that predict distant recurrence risk via FISH assays in women with early stage breast carcinoma

2007

Conference Poster

Adolescent and young adult cancer data in the Cancer Research Network [poster]

2017

Crusade for cancer data: how a non-SEER Site populated the VDW tumor table [poster]

2017

Long-term outcomes of a cluster-randomized trial testing the effects of blood pressure (BP) telemonitoring and pharmacist management on BP outcomes [poster]

2017

Long-term outcomes of a cluster-randomized trial testing the effects of blood pressure telemonitoring and pharmacist management [poster]

2017

Cancer Research Network: data availability pre- and post-cancer diagnosis [poster]

2014

Pharmacogenomic testing in patients with chronic pain to support personalized medicine [poster]

2014

Validation of colony stimulating factor (G-CSF) data within the HMORN Virtual Data Warehouse [poster]

2014

Identification of severe cutaneous reactions and genomic risk factors in users of antiepileptic drugs [poster]

2013

Pharmacogenomic testing in patients with chronic pain to support personalized medicine [poster]

2013

Drug characteristics associated with medication adherence across eight disease states [poster]

2012

Drug characteristics associated with medication adherence across eight disease states [poster]

2012

Evaluating the quality of VDW pharmacy data [poster]

2012

Trends in elective labor induction at 7 US health plans, 2001-2007 [poster]

2012

Medication adherence across eight disease states within an integrated health system [poster]

2010

Medication exposure in a pregnancy risk evaluation program [poster]

2010

Medication exposure in a pregnancy risk evaluation program [poster]

2010

The Minnesota Memory Project [poster]

2010

The interaction of age and comorbidity with breast cancer severity: their impact on radiotherapy utilization and rate of recurrence among older women with early stage breast cancer [poster]

2010

Utilization and effectiveness of KRAS testing for colorectal cancer [poster]

2010

Medication therapy management (MTM): an evaluation of medicare part d member response and participation [poster]

2009

Review

A systematic review of clinical decision support systems for clinical oncology practice [systematic review].

Journal of the National Comprehensive Cancer Network. 2019

Abstract

Beyond implementation: developing and utilizing a 5-factor scale to measure optimization of Lynch syndrome tumor screening programs in health systems [abstract].

Journal of patient-centered research and reviews. 2021

Comparing change in systolic blood pressure with clinic-based care versus telehealth care in a pragmatic cluster-randomized trial (Hyperlink 3) [abstract].

Journal of patient-centered research and reviews. 2021

Medication adherence during the COVID-19 pandemic: preliminary data from the patient perspective [abstract].

Journal of patient-centered research and reviews. 2021

Diagnosis and treatment of neuropathy postchemotherapy in three health systems [abstract].

Journal of patient-centered research and reviews. 2019

Long-term effects on cardiovascular events of home blood pressure telemonitoring with pharmacist management in patients with uncontrolled hypertension [abstract].

Journal of patient-centered research and reviews. 2019

Tumor characteristics and treatment in early-onset colorectal cancer [abstract].

Journal of Clinical Oncology. 2018

Assessing the adoption and application of the 2013 ACC/AHA guidelines for statin prescribing [abstract].

Journal of Managed Care Pharmacy. 2017

Opioid prescribing during pregnancy: eight-year secular trends at HealthPartners Medical Group [abstract].

Journal of patient-centered research and reviews. 2017

Application of statin medication adherence trajectory models in an integrated financing and care delivery system [abstract].

Pharmacotherapy. 2016

Clinical and demographic characteristics of patients receiving opioid therapy during pregnancy [abstract].

Pharmacotherapy. 2016

Qualitative data from a trial of home blood pressure telemonitoring and pharmacist management (Hyperlink) [abstract].

Journal of patient-centered research and reviews. 2016

Retrospective analysis of a multidisciplinary antihypertensive protocol [abstract].

Journal of Managed Care Pharmacy. 2016

Chemotherapy treatment patterns among advanced colon cancer patients [abstract].

Clinical Medicine & Research. 2012

Evaluation of the validity of the gestational length assumptions based upon ddministrative health plan data [abstract].

Clinical Medicine & Research. 2012

A feasibility pilot to determine the practicality of using the HMO Research Network to research the genetics of drug-induced serious adverse events [abstract].