Potential negative effects of epinephrine on carotid blood flow and ETCO2 during active compression-decompression CPR utilizing an impedance threshold device Journal Article uri icon
Overview
abstract
  • OBJECTIVES: This study examines the effects of IV epinephrine administration on carotid blood flow (CBF) and end tidal CO(2) (ETCO(2)) production in a swine model of active compression-decompression CPR with an impedance threshold device (ACD-CPR+ITD). METHODS: Six female swine (32 ± 1 kg) were anesthetized, intubated and ventilated. Intracranial, thoracic aorta and right atrial pressures were measured via indwelling catheters. CBF was recorded. ETCO(2), SpO(2) and EKG were monitored. V-fib was induced and went untreated for 6 min. Three minutes each of standard CPR (STD), STD-CPR+impedance threshold device (ITD) and active compression-decompression (ACD)-CPR+ITD were performed. At minute 9 of the resuscitation, 40 μg/kg of IV Epinephrine was administered and ACD-CPR+ITD was continued for 1 min. Statistical analysis was performed with a paired t-test. p values of <0.05 were considered statistically significant and all values are reported in mmHg unless otherwise noted. RESULTS: Aortic pressure, cerebral and coronary perfusion pressures increased from STD

  • Link to Article
    publication date
  • 2012
  • published in
  • Resuscitation  Journal
  • Research
    keywords
  • Adverse Effects
  • Animal Studies
  • Cardiovascular Diseases
  • Drugs and Drug Therapy
  • Emergency Medicine
  • Resuscitation
  • Additional Document Info
    volume
  • 83
  • issue
  • 8