Overview/research interests: Intranasal delivery of therapeutics to treat and prevent brain damage from Alzheimer’s disease, Parkinson’s disease, stroke, traumatic brain injury, posttraumatic stress disorder, brain tumors and other brain disorders.
- Developed noninvasive, intranasal method for bypassing the blood-brain barrier to target central nervous system therapeutic agents to the brain and spinal cord while reducing system exposure and unwanted side effects
- Developed and patented intranasal insulin and showed that intranasal insulin improves memory in patients with Alzheimer’s disease
- Developed and patented method using intranasal insulin to treat and protect against traumatic brain injury
- Developed method using intranasal insulin to treat and protect against posttraumatic stress disorder
- Developed and patented intranasal deferoxamine for the treatment of Alzheimer’s disease, stroke, Parkinson’s disease, traumatic brain injury and other central nervous system disorders
- Developed and patented intranasal stem cells to bypass the blood-brain barrier and treat Parkinson’s disease, stroke, Alzheimer’s disease and other central nervous system disorders
- Leading expert in why humans uniquely evolved the ability to shed emotional tears in response to stress and the chemistry of emotional tears
- Research has been subject of articles in the New York Times, Wall Street Journal, U.S. News and World Report and numerous other newspapers and magazines
- Interviewed on the Today Show, Good Morning America, 20/20, All Things Considered, the BBC and numerous other TV and radio programs around the world
Current research activities and funding: Intranasal delivery of therapeutics to treat and prevent brain damage from Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, stroke, traumatic brain injury, posttraumatic stress syndrome and other central nervous system disorders.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
2023
Drug delivery.
2022
Journal of Neurosurgery.
2022
Developmental Neuroscience.
2022
Drugs and Aging.
2021
Frontiers in Molecular Neuroscience.
2021
Pharmaceuticals (Basel, Switzerland).
2021
Translational psychiatry.
2021
Cells.
2020
EBioMedicine.
2020
Drugs in R&D.
2020
Brain and behavior.
2020
Neuroscience Letters.
2020
PloS One.
2020
Neurotherapeutics.
2019
ACS Chemical Neuroscience.
2019
Journal of Alzheimer's disease reports.
2018
Human Gene Therapy.
2017
Journal of the Neurological Sciences.
2017
Journal of Cerebral Blood Flow and Metabolism.
2017
Neuroscience Letters.
2016
Neurotoxicology.
2016
2016
Cephalalgia.
2016
Neuroscience Letters.
2015
2015
2015
Neuroscience.
2014
Molecular Pain.
2014
CNS drugs.
2014
Cell Transplantation.
2014
AAPS (American Association of Pharmaceutical Scientists) Newsmagazine.
2014
Minn Physician.
2014
Brain Research.
2014
2014
Molecular Pain.
2012
Experimental Brain Research.
2012
Drug delivery and translational research.
2012
Drug delivery.
2012
Journal of Pharmacy and Pharmacology.
2012
Neuroscience Letters.
2012
Molecular Genetics and Metabolism.
2012
Minn Physician.
2012
Neurobiology of Disease.
2012
AAPS (American Association of Pharmaceutical Scientists) Newsmagazine.
2011
Journal of Neuroscience.
2011
Journal of Molecular Neuroscience.
2011
Journal of Neuropathology and Experimental Neurology.
2011
Rejuvenation research.
2011
Molecular Pain.
2010
Journal of Drug Targeting.
2010
Drug Deliv Technol.
2010
Rejuvenation research.
2010
Molecular Pharmaceutics.
2010
Archives of Biochemistry and Biophysics.
2009
Journal of Pharmacology and Experimental Therapeutics.
2009
European Journal of Cell Biology.
2009
Journal of Pharmaceutical Sciences.
2009
Journal of Pharmacology and Experimental Therapeutics.
2009
Neuroscience.
2008
Neuroscience Letters.
2008
BMC Neuroscience.
2008
Journal of Alzheimer's Disease.
2008
Neuro-Oncology.
2008
2007
2007
2007
2007
2007
Journal of Molecular Neuroscience.
2005
Journal of Neuroimmunology.
2004
Journal of Stroke and Cerebrovascular Diseases.
2004
Brain Research.
2002
Neuroscience Letters.
2001
Acta Neuropathologica.
2000
Neurology.
2000
Brain Research.
1996
Brain Research.
1995
Journal of Geriatric Psychiatry and Neurology.
1994
Molecular and Chemical Neuropathology.
1994
Brain Research.
1994
Journal of Geriatric Psychiatry and Neurology.
1994
Clinical and Diagnostic Laboratory Immunology.
1994
Clinical and Diagnostic Laboratory Immunology.
1994
Journal of Neuroimmunology.
1994
Neurology.
1993
Journal of Immunological Methods.
1993
Journal of the American Geriatrics Society.
1992
Neurochemical Research.
1992
Alzheimer Disease and Associated Disorders.
1992
Human Molecular Genetics.
1992
Neurology.
1992
Brain Research Bulletin.
1992
Neurology.
1992
Journal of Geriatric Psychiatry and Neurology.
1991
International Psychogeriatrics.
1991
Neurology.
1990
Archives of Neurology.
1990
Alzheimer Disease and Associated Disorders.
1990
Journal of Neurochemistry.
1987
Neurology.
1987
Neurochemical Research.
1985
Neurochemical Research.
1985
Biological Psychiatry.
1982
Journal of Neurochemistry.
1981
Biochimica et Biophysica Acta.
1981
Journal of Neurochemistry.
1980
Expert Review of Clinical Pharmacology.
5.
2012
Archives of Neurology.
53.
1996
Annals of Neurology.
36.
1994
JAMA.
263.
1990
Lancet (London, England).
1.
1985
2013
2013
2013
2013
2013
2007
2013
2013
2013
2012
2011
2010
2010
2010
Pharmaceuticals (Basel, Switzerland).
2022
Pharmaceuticals (Basel, Switzerland).
2021
Neurotherapeutics.
2020
Headache.
2017
CNS drugs.
2013
Journal of Nervous and Mental Disease.
2013
Pharmaceutical Research.
2013
Molecular Neurobiology.
2012
Frontiers in bioscience (Scholar edition).
2012
Experimental Gerontology.
2011
Journal of Pharmaceutical Sciences.
2010
BMC Neuroscience.
2008
2007
Journal of Neuroimmune Pharmacology.
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2021
2021
2021
2021
2017
2014
2014
2014
2014
2014
Geographic Focus
- Minnesota State or Province